ANALGESIC ACTIVITY TEST OF WARU (Hibiscus tiliaceus L.) LEAVES ETHANOL EXTRACT IN MALE WHITE MISCULES (Mus musculus)

Herbal remedies in therapy have been used the treatment of pain since time immemorial. Pain is a sensory and emotional event that causes discomfort due to tissue damage. Most analgesics modern medicine side effects on either gastro-intestinal tract or nervous system. Empirically waru leaves as traditional medicine. The purpose this study was evaluate analgesic effect ethanol extract leaf compare it with mefenamic acid tablets then measured by plantar test infra red (IR) 96 nm. Twenty five mice were divided into groups. Three them treated doses 100, 200, 300 mg/kgbw, 0.5% Na-CMC (negative control), 500 mg Mefenamic Acid (positive control). Infrared induction performed every 10 minutes for 60 minutes. maximum activity indicated dose mg/kg body weight at which 23.8 where effectiveness almost same standard drug Acid, 24.3 while 200 mg/kgBB 20.9 100 mg/kgBW 19.9. data obtained processed using one way ANOVA. conclusion revealed hibiscus (Hibiscus tiliaceus L.) has significant properties, especially higher